DHX38

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 is an enzyme that in humans is encoded by the DHX38 gene.^[5][6][7]

DHX38
Identifiers
Aliases	DHX38, DDX38, PRP16, PRPF16, DEAH-box helicase 38, RP84
External IDs	OMIM: 605584; MGI: 1927617; HomoloGene: 8512; GeneCards: DHX38; OMA:DHX38 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.2 Start 72,093,613 bp[1] End 72,112,912 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D3 Start 110,274,643 bp[2] End 110,292,493 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve left ovary right ovary granulocyte apex of heart Achilles tendon body of uterus skin of leg skin of abdomen left uterine tube Top expressed in granulocyte tail of embryo zygote neural layer of retina ventricular zone yolk sac epiblast secondary oocyte spermatid spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding helicase activity protein binding nucleic acid binding hydrolase activity ATP binding RNA binding 3'-5' RNA helicase activity Cellular component catalytic step 2 spliceosome membrane nucleoplasm spliceosomal complex nucleus cytoplasm Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing mRNA export from nucleus mRNA 3'-end processing RNA splicing RNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9785 64340 Ensembl ENSG00000140829 ENSMUSG00000037993 UniProt Q92620 Q80X98 RefSeq (mRNA) NM_014003 NM_178380 RefSeq (protein) NP_054722 NP_848467 Location (UCSC) Chr 16: 72.09 – 72.11 Mb Chr 8: 110.27 – 110.29 Mb PubMed search [3] [4]
Wikidata
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DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process.^[7]