DIO2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

DIO2

Type II iodothyronine deiodinase (iodothyronine 5'-deiodinase, iodothyronine 5'-monodeiodinase) is an enzyme that in humans is encoded by the DIO2 gene.[5][6][7]

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DIO2
Identifiers
AliasesDIO2, 5DII, D2, DIOII, SelY, TXDI2, deiodinase, iodothyronine, type II, iodothyronine deiodinase 2, SELENOY
External IDsOMIM: 601413; MGI: 1338833; HomoloGene: 621; GeneCards: DIO2; OMA:DIO2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_010050

RefSeq (protein)

NP_000784
NP_001311391
NP_054644
NP_001353425

NP_034180

Location (UCSC)Chr 14: 80.2 – 80.39 MbChr 12: 90.69 – 90.71 Mb
PubMed search[3][4]
Wikidata
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Function

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves' disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the Sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

DIO2 has been shown to interact with USP33.[8]

See also

References

Further reading

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