DIRC2

Disrupted in renal carcinoma 2 is a protein that in humans is encoded by the DIRC2 gene.^[5]

SLC49A4
Identifiers
Aliases	SLC49A4, RCC4, disrupted in renal carcinoma 2, solute carrier family 49 member 4, DIRC2
External IDs	OMIM: 602773; MGI: 2387188; HomoloGene: 13137; GeneCards: SLC49A4; OMA:SLC49A4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.1 Start 122,795,069 bp[1] End 122,881,139 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 35,514,432 bp[2] End 35,589,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte skin of arm placenta decidua tibialis anterior muscle cardiac muscle tissue of right atrium deltoid muscle pancreatic epithelial cell myocardium of left ventricle gingival epithelium Top expressed in muscle of thigh sternocleidomastoid muscle triceps brachii muscle gastrocnemius muscle interventricular septum quadriceps femoris muscle temporal muscle knee joint vastus lateralis muscle skeletal muscle tissue More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 84925 224132 Ensembl ENSG00000138463 ENSMUSG00000022848 UniProt Q96SL1 Q8BFQ6 RefSeq (mRNA) NM_032839 NM_153550 RefSeq (protein) NP_116228 NP_705778 Location (UCSC) Chr 3: 122.8 – 122.88 Mb Chr 16: 35.51 – 35.59 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas.^[5]