DIS3

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene.^[5][6] Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic cells.^[7][8]

DIS3
Identifiers
Aliases	DIS3, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
External IDs	OMIM: 607533; MGI: 1919912; HomoloGene: 6910; GeneCards: DIS3; OMA:DIS3 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q21.33 Start 72,752,169 bp[1] End 72,782,096 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 E2.2 Start 99,312,642 bp[2] End 99,337,206 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm Achilles tendon ventricular zone testicle stromal cell of endometrium ganglionic eminence rectum islet of Langerhans popliteal artery tibial arteries Top expressed in primitive streak spermatid epiblast tail of embryo seminiferous tubule somite abdominal wall genital tubercle endothelial cell of lymphatic vessel Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity hydrolase activity guanyl-nucleotide exchange factor activity exonuclease activity RNA binding protein binding endonuclease activity 3'-5'-exoribonuclease activity ribonuclease activity Cellular component nucleolus nucleoplasm cytoplasm exosome (RNase complex) nuclear exosome (RNase complex) membrane nucleus cytosol cytoplasmic exosome (RNase complex) Biological process exonucleolytic catabolism of deadenylated mRNA regulation of mRNA stability CUT catabolic process rRNA processing rRNA catabolic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, exonucleolytic regulation of molecular function RNA catabolic process RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22894 72662 Ensembl ENSG00000083520 ENSMUSG00000033166 UniProt Q9Y2L1 Q9CSH3 RefSeq (mRNA) NM_001128226 NM_014953 NM_001322348 NM_001322349 NM_028315 NM_001360050 NM_001360051 RefSeq (protein) NP_001121698 NP_001309277 NP_001309278 NP_055768 NP_082591 NP_001346979 NP_001346980 Location (UCSC) Chr 13: 72.75 – 72.78 Mb Chr 14: 99.31 – 99.34 Mb PubMed search [3] [4]
Wikidata
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