DIXDC1

Dixin is a protein that in humans is encoded by the DIXDC1 gene.^[5][6] When active it stops cancer metastasis due to extreme stickiness, both in vitro and in vivo.^[7]

DIXDC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3PZ7
Identifiers
Aliases	DIXDC1, CCD1, DIX domain containing 1
External IDs	OMIM: 610493; MGI: 2679721; HomoloGene: 82369; GeneCards: DIXDC1; OMA:DIXDC1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,927,144 bp[1] End 112,022,653 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 50,574,052 bp[2] End 50,650,817 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon inferior ganglion of vagus nerve corpus callosum urethra saphenous vein superficial temporal artery subthalamic nucleus ventral tegmental area synovial joint mucosa of paranasal sinus Top expressed in lobe of cerebellum cerebellar vermis habenula superior colliculus pontine nuclei epithelium of lens dorsomedial hypothalamic nucleus ventral tegmental area neural layer of retina medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding gamma-tubulin binding protein binding protein domain specific binding Cellular component cytosol cell junction focal adhesion cytoplasm cytoskeleton Biological process positive regulation of canonical Wnt signaling pathway multicellular organism development positive regulation of Wnt signaling pathway regulation of microtubule cytoskeleton organization forebrain ventricular zone progenitor cell division cerebral cortex radially oriented cell migration cerebral cortex cell migration regulation of actin cytoskeleton organization negative regulation of neuron differentiation Wnt signaling pathway cell proliferation in forebrain canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 85458 330938 Ensembl ENSG00000150764 ENSMUSG00000032064 UniProt Q155Q3 Q80Y83 RefSeq (mRNA) NM_001037954 NM_001278542 NM_033425 NM_178118 NM_001311069 NM_001374656 RefSeq (protein) NP_001033043 NP_001265471 NP_219493 NP_001297998 NP_835219 NP_001361585 Location (UCSC) Chr 11: 111.93 – 112.02 Mb Chr 9: 50.57 – 50.65 Mb PubMed search [3] [4]
Wikidata
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