DKK3

Dickkopf-related protein 3 is a protein in the Dickkopf family that in humans is encoded by the DKK3 gene.^[5][6]

DKK3
Identifiers
Aliases	DKK3, REIC, RIG, dickkopf WNT signaling pathway inhibitor 3, CRRL
External IDs	OMIM: 605416; MGI: 1354952; HomoloGene: 8303; GeneCards: DKK3; OMA:DKK3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.3 Start 11,956,207 bp[1] End 12,009,769 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F1 Start 111,715,224 bp[2] End 111,758,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 middle temporal gyrus lateral nuclear group of thalamus external globus pallidus right auricle of heart tendon of biceps brachii entorhinal cortex pars compacta vena cava Top expressed in epithelium of lens ciliary body iris neural layer of retina aortic valve calvaria ascending aorta utricle dentate gyrus of hippocampal formation granule cell primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function co-receptor binding receptor antagonist activity Cellular component extracellular region extracellular space Biological process negative regulation of anti-Mullerian hormone signaling pathway multicellular organism development negative regulation of cortisol biosynthetic process negative regulation of Wnt signaling pathway anatomical structure morphogenesis negative regulation of transcription, DNA-templated Wnt signaling pathway adrenal gland development negative regulation of canonical Wnt signaling pathway regulation of transforming growth factor beta receptor signaling pathway negative regulation of aldosterone biosynthetic process extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27122 50781 Ensembl ENSG00000050165 ENSMUSG00000030772 UniProt Q9UBP4 Q9QUN9 RefSeq (mRNA) NM_001018057 NM_013253 NM_015881 NM_001330220 NM_015814 NM_001360257 NM_001360260 NM_001360261 RefSeq (protein) NP_001018067 NP_001317149 NP_037385 NP_056965 NP_056629 NP_001347186 NP_001347189 NP_001347190 Location (UCSC) Chr 11: 11.96 – 12.01 Mb Chr 7: 111.72 – 111.76 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein.^[6]