DLGAP5

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a protein that in humans is encoded by the DLGAP5 gene.^[5][6][7][8]

DLGAP5
Identifiers
Aliases	DLGAP5, DLG7, HURP, discs large homolog associated protein 5, DLG associated protein 5
External IDs	OMIM: 617859; MGI: 2183453; HomoloGene: 8840; GeneCards: DLGAP5; OMA:DLGAP5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 55,148,112 bp[1] End 55,191,608 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C1|14 24.6 cM Start 47,625,236 bp[2] End 47,655,864 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone gonad embryo ganglionic eminence trabecular bone testicle bone marrow bone marrow cells sperm Top expressed in tail of embryo zygote genital tubercle primary oocyte yolk sac secondary oocyte ventricular zone blastocyst epiblast fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphoprotein phosphatase activity Cellular component microtubule organizing center nucleus cytoskeleton spindle spindle pole centrosome cytoplasm mitochondrion cytosol Biological process positive regulation of mitotic metaphase/anaphase transition cell cycle mitotic chromosome movement towards spindle pole cell population proliferation signaling protein dephosphorylation positive regulation of transcription of Notch receptor target Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9787 218977 Ensembl ENSG00000126787 ENSMUSG00000037544 UniProt Q15398 Q8K4R9 RefSeq (mRNA) NM_001146015 NM_014750 NM_001145949 NM_144553 RefSeq (protein) NP_001139487 NP_055565 NP_653136 Location (UCSC) Chr 14: 55.15 – 55.19 Mb Chr 14: 47.63 – 47.66 Mb PubMed search [3] [4]
Wikidata
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DLG7 is a kinetochore protein that stabilizes microtubules in vicinity of chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture.^[9] DGL7 is a part of Ran-dependent complex.^[10] Stabilization of DGL7 in cell occurs due to phosphorylation by Aurora A kinase.^[11] Expression of DGL7 is found in cancer^[12] and stem cells.^[13]