DLK1

Protein delta homolog 1, delta like non-canonical Notch ligand 1, fetal antigen 1^[5] or preadipocyte factor 1^[6] is a protein that in humans is encoded by the DLK1 gene.^[7][8][9]

DLK1
Identifiers
Aliases	DLK1, DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2, AW742678, DlkI, Ly107, Peg9, SCP1, delta like non-canonical Notch ligand 1
External IDs	OMIM: 176290; MGI: 94900; HomoloGene: 2846; GeneCards: DLK1; OMA:DLK1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.2 Start 100,725,705 bp[1] End 100,738,224 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 60.17 cM Start 109,418,749 bp[2] End 109,429,262 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal cortex anterior pituitary cartilage tissue beta cell glutes left ovary placenta parotid gland body of tongue Top expressed in yolk sac adrenal gland hypothalamus placenta neural tube mesencephalon genital tubercle limb rhombencephalon tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding molecular function Cellular component integral component of membrane membrane extracellular space cytoplasm Biological process cell differentiation negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8788 13386 Ensembl ENSG00000185559 ENSMUSG00000040856 UniProt P80370 Q09163 RefSeq (mRNA) NM_001032997 NM_003836 NM_001317172 NM_001190703 NM_001190704 NM_001190705 NM_010052 RefSeq (protein) NP_001304101 NP_003827 NP_003827.3 NP_001177632 NP_001177633 NP_001177634 NP_034182 Location (UCSC) Chr 14: 100.73 – 100.74 Mb Chr 12: 109.42 – 109.43 Mb PubMed search [3] [4]
Wikidata
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It is expressed as a transmembrane protein, but a soluble form cleaved off by ADAM17 is active in inhibiting adipogenesis,^[10] the differentiation of pre-adipocytes into adipocytes.^[11]

It is a member of the EGF-like family of homeotic proteins.^[12]

Part of the Dlk1-DIO3 imprinting control region, this gene is one involved in the epigenetic process that causes a subset of genes to be regulated based on their parental origin.^[13]

Such imprinted genes are required for the formation of the placenta as well as the development of cellular lineages such as those derived from the mesoderm and ectoderm.^[14]