DLL4

Delta-like 4 is a protein that in humans is encoded by the DLL4 gene.^[5][6]

DLL4
Identifiers
Aliases	DLL4, hdelta2, AOS6, delta like canonical Notch ligand 4, delta4
External IDs	OMIM: 605185; MGI: 1859388; HomoloGene: 10411; GeneCards: DLL4; OMA:DLL4 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 40,929,340 bp[1] End 40,939,073 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,156,265 bp[2] End 119,166,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava apex of heart body of tongue pericardium upper lobe of left lung subcutaneous adipose tissue left ventricle atrium right atrium cardia Top expressed in interventricular septum vasculature of trunk lamina propria of small intestine umbilical artery dorsal aorta right lung endothelium of artery right ventricle gastrula right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding Notch binding protein binding Cellular component integral component of membrane membrane plasma membrane Biological process Notch signaling pathway dorsal aorta morphogenesis cell differentiation negative regulation of blood vessel endothelial cell migration response to stimulus negative regulation of transcription by RNA polymerase II blood vessel lumenization cellular response to fibroblast growth factor stimulus blood circulation negative regulation of gene expression nervous system development ventricular trabecula myocardium morphogenesis negative regulation of endothelial cell migration regulation of neural retina development positive regulation of neural precursor cell proliferation negative regulation of cell migration involved in sprouting angiogenesis cell communication multicellular organism development blood vessel remodeling T cell differentiation positive regulation of gene expression ventral spinal cord interneuron fate commitment angiogenesis pericardium morphogenesis negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis branching involved in blood vessel morphogenesis cellular response to vascular endothelial growth factor stimulus cardiac atrium morphogenesis cardiac ventricle morphogenesis regulation of neurogenesis signal transduction visual perception negative regulation of cell population proliferation negative regulation of Notch signaling pathway positive regulation of Notch signaling pathway Notch signaling involved in heart development aortic valve morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54567 54485 Ensembl ENSG00000128917 ENSMUSG00000027314 UniProt Q9NR61 Q9JI71 RefSeq (mRNA) NM_019074 NM_019454 RefSeq (protein) NP_061947 NP_062327 Location (UCSC) Chr 15: 40.93 – 40.94 Mb Chr 2: 119.16 – 119.17 Mb PubMed search [3] [4]
Wikidata
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This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.^[6]