DNAI7

Dynein axonemal intermediate chain 7 is a protein that in humans is encoded by the DNAI7 gene, also sometimes known as LAS1; CASC1; CFAP94; or PPP1R54. The protein is sometimes referred to as cancer susceptibility 1.^[5]

DNAI7
Identifiers
Aliases	DNAI7, LAS1, PPP1R54, cancer susceptibility candidate 1, cancer susceptibility 1, cilia and flagella associated protein 94, CASC1, dynein axonemal intermediate chain 7, CFAP94
External IDs	OMIM: 616906; MGI: 2444480; HomoloGene: 41242; GeneCards: DNAI7; OMA:DNAI7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p12.1 Start 25,108,289 bp[1] End 25,195,162 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 G3|6 77.37 cM Start 145,120,560 bp[2] End 145,156,731 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm bronchial epithelial cell right uterine tube olfactory zone of nasal mucosa testicle buccal mucosa cell mucosa of paranasal sinus left testis right testis Epithelium of choroid plexus Top expressed in zygote secondary oocyte primary oocyte spermatid spermatocyte testicle ovary hypothalamus granulocyte embryo More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 55259 320662 Ensembl ENSG00000118307 ENSMUSG00000043541 UniProt Q6TDU7 Q6TDU8 RefSeq (mRNA) NM_001082972 NM_001082973 NM_001204101 NM_001204102 NM_018272 NM_001319977 NM_001319978 NM_001352061 NM_001352062 NM_001352063 NM_001352064 NM_001352065 NM_001352066 NM_001352067 NM_001352068 NM_177222 RefSeq (protein) NP_001076441 NP_001076442 NP_001191030 NP_001191031 NP_001306906 NP_001306907 NP_060742 NP_001338990 NP_001338991 NP_001338992 NP_001338993 NP_001338994 NP_001338995 NP_001338996 NP_001338997 NP_796196 Location (UCSC) Chr 12: 25.11 – 25.2 Mb Chr 6: 145.12 – 145.16 Mb PubMed search [3] [4]
Wikidata
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Casc1, alias Las1, is one of the six genes constituting the mouse Pulmonary adenoma susceptibility 1 (Pas1) locus haplotype.^[6]