DNAJA2

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.^[5][6][7]

DNAJA2
Identifiers
Aliases	DNAJA2, CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2, DnaJ heat shock protein family (Hsp40) member A2
External IDs	OMIM: 611322; MGI: 1931882; HomoloGene: 21193; GeneCards: DNAJA2; OMA:DNAJA2 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q11.2 Start 46,955,362 bp[1] End 46,973,674 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 86,264,262 bp[2] End 86,281,973 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle endothelial cell sperm muscle of thigh Skeletal muscle tissue of rectus abdominis germinal epithelium mucosa of paranasal sinus right auricle of heart prefrontal cortex Top expressed in neural layer of retina triceps brachii muscle sternocleidomastoid muscle medial ganglionic eminence temporal muscle digastric muscle urothelium abdominal wall transitional epithelium of urinary bladder atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding chaperone binding protein binding ATP binding heat shock protein binding metal ion binding ATPase activator activity Cellular component extracellular exosome membrane cytosol Biological process response to heat protein folding protein refolding positive regulation of cell population proliferation positive regulation of ATP-dependent activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10294 56445 Ensembl ENSG00000069345 ENSMUSG00000031701 UniProt O60884 Q9QYJ0 RefSeq (mRNA) NM_005880 NM_019794 RefSeq (protein) NP_005871 NP_062768 Location (UCSC) Chr 16: 46.96 – 46.97 Mb Chr 8: 86.26 – 86.28 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products.^[7]