DNA polymerase nu

Polymerase (DNA directed) nu is a protein in humans that is encoded by the POLN gene.^[5] It is a family A DNA polymerase,^[6] considered to be the least effective of the polymerase enzymes.^[7] However, DNA polymerase nu plays an active role in homology repair during cellular responses to crosslinks, fulfilling its role in a complex with helicase.^[7]

POLN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XVI, 4XVK, 4XVL, 4XVM
Identifiers
Aliases	POLN, POL4P, polymerase (DNA) nu, DNA polymerase nu
External IDs	OMIM: 610887; MGI: 2675617; HomoloGene: 129696; GeneCards: POLN; OMA:POLN - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.3 Start 2,071,918 bp[1] End 2,242,121 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B2 Start 34,164,523 bp[2] End 34,326,792 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caudate nucleus putamen nucleus accumbens right frontal lobe Brodmann area 9 testicle anterior cingulate cortex left testis right testis cerebellar hemisphere Top expressed in spermatocyte spermatid brown adipose tissue seminiferous tubule lens lumbar subsegment of spinal cord white adipose tissue primary oocyte zygote epithelium of lens More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding nucleotidyltransferase activity 5'-3' exonuclease activity protein binding cyclin binding DNA-directed DNA polymerase activity nucleic acid binding Cellular component cytoplasm nucleolus nucleoplasm nucleus Biological process cellular response to DNA damage stimulus DNA replication double-strand break repair via homologous recombination DNA repair DNA-dependent DNA replication interstrand cross-link repair translesion synthesis nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 353497 272158 Ensembl ENSG00000130997 ENSMUSG00000045102 UniProt Q7Z5Q5 Q7TQ07 RefSeq (mRNA) NM_181808 NM_001289803 NM_001289804 NM_181857 RefSeq (protein) NP_861524 NP_001276732 NP_001276733 NP_862905 Location (UCSC) Chr 4: 2.07 – 2.24 Mb Chr 5: 34.16 – 34.33 Mb PubMed search [3] [4]
Wikidata
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