DNPEP

Aspartyl aminopeptidase is an enzyme that in humans is encoded by the DNPEP gene.^[5][6]

DNPEP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DYO
Identifiers
Aliases	DNPEP, ASPEP, DAP, aspartyl aminopeptidase
External IDs	OMIM: 611367; MGI: 1278328; HomoloGene: 6110; GeneCards: DNPEP; OMA:DNPEP - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,372,043 bp[1] End 219,400,022 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 75,284,540 bp[2] End 75,294,634 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis canal of the cervix gastric mucosa apex of heart mucosa of transverse colon right ovary left uterine tube upper lobe of left lung ectocervix Top expressed in intestinal villus internal carotid artery external carotid artery Rostral migratory stream epithelium of small intestine aortic valve ascending aorta lobe of prostate gastrula endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity zinc ion binding aminopeptidase activity protein binding hydrolase activity metallopeptidase activity metal ion binding metalloaminopeptidase activity identical protein binding Cellular component blood microparticle nucleus cytosol cytoplasm extracellular region Biological process proteolysis peptide metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23549 13437 Ensembl ENSG00000123992 ENSMUSG00000026209 UniProt Q9ULA0 Q9Z2W0 RefSeq (mRNA) NM_012100 NM_001319116 NM_001319117 NM_001319118 NM_001319119 NM_001319120 NM_001319121 NM_001319122 NM_001110831 NM_016878 RefSeq (protein) NP_001306045 NP_001306046 NP_001306047 NP_001306048 NP_001306049 NP_001306050 NP_001306051 NP_036232 NP_001306050.1 NP_001306051.1 NP_001104301 NP_058574 Location (UCSC) Chr 2: 219.37 – 219.4 Mb Chr 1: 75.28 – 75.29 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an aminopeptidase which prefers acidic amino acids, and specifically favors aspartic acid over glutamic acid. It is thought to be a cytosolic protein involved in the general metabolism of intracellular proteins.^[6]

See also

• Biology portal