DOK1

Docking protein 1 is a protein that in humans is encoded by the DOK1 gene.^[5][6][7]

DOK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V76
Identifiers
Aliases	DOK1, P62DOK, pp62, docking protein 1
External IDs	OMIM: 602919; MGI: 893587; HomoloGene: 1057; GeneCards: DOK1; OMA:DOK1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,549,026 bp[1] End 74,557,551 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3|6 35.94 cM Start 83,007,915 bp[2] End 83,010,452 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii pancreatic ductal cell monocyte granulocyte vena cava blood body of tongue internal globus pallidus spleen Skeletal muscle tissue of rectus abdominis Top expressed in stroma of bone marrow granulocyte mesenteric lymph nodes otic vesicle spleen fossa calvaria endothelial cell of lymphatic vessel thymus condyle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component perinuclear region of cytoplasm nucleus cytoplasm cytosol Biological process cell surface receptor signaling pathway Ras protein signal transduction intracellular signal transduction signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of epidermal growth factor receptor signaling pathway axon guidance macrophage colony-stimulating factor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1796 13448 Ensembl ENSG00000115325 ENSMUSG00000068335 UniProt Q99704 P97465 RefSeq (mRNA) NM_001197260 NM_001381 NM_001318866 NM_001318867 NM_001318868 NM_001318869 NM_001291799 NM_010070 RefSeq (protein) NP_001184189 NP_001305795 NP_001305796 NP_001305797 NP_001305798 NP_001372 NP_001278728 NP_034200 Location (UCSC) Chr 2: 74.55 – 74.56 Mb Chr 6: 83.01 – 83.01 Mb PubMed search [3] [4]
Wikidata
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Function

Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.^[8]

Interactions

DOK1 has been shown to interact with:

• ABL1^[9][10] and
• CD117,^[11]
• INPP5D,^[9][12]
• LYN,^[9][11]
• RASA1,^[10][12][13]
• RET,^[14]
• SH2D1A,^[15]
• SHC1,^[12] and
• TEC.^[9][11]