DOK5

Docking protein 5 is a protein that in humans is encoded by the DOK5 gene.^[5][6]

DOK5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1J0W
Identifiers
Aliases	DOK5, C20orf180, IRS-6, IRS6, docking protein 5
External IDs	OMIM: 608334; MGI: 1924079; HomoloGene: 10195; GeneCards: DOK5; OMA:DOK5 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.2 Start 54,475,593 bp[1] End 54,651,169 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 92.26 cM Start 170,573,727 bp[2] End 170,721,689 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence pancreatic ductal cell vastus lateralis muscle cartilage tissue Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii deltoid muscle Brodmann area 46 Top expressed in ventricular zone visual cortex primary visual cortex soleus muscle superior frontal gyrus genital tubercle dentate gyrus of hippocampal formation granule cell neural tube neural layer of retina embryo More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 55816 76829 Ensembl ENSG00000101134 ENSMUSG00000027560 UniProt Q9P104 Q91ZM9 RefSeq (mRNA) NM_001294161 NM_018431 NM_177959 NM_001163686 NM_029761 RefSeq (protein) NP_001281090 NP_060901 NP_808874 NP_001157158 NP_084037 Location (UCSC) Chr 20: 54.48 – 54.65 Mb Chr 2: 170.57 – 170.72 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. In contrast to other DOK family proteins, this protein does not interact with RASGAP.^[6]

Interactions

DOK5 has been shown to interact with RET proto-oncogene.^[5][7]