DOM3Z

Protein Dom3Z is a protein that in humans is encoded by the DOM3Z gene.^[5][6]

DXO
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FQI, 3FQJ, 4J7L, 4J7M, 4J7N
Identifiers
Aliases	DXO, DOM3L, DOM3Z, NG6, RAI1, decapping exoribonuclease
External IDs	OMIM: 605996; MGI: 1890444; HomoloGene: 38061; GeneCards: DXO; OMA:DXO - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 31,969,810 bp[1] End 31,972,290 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 35,055,995 bp[2] End 35,058,209 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis pituitary gland anterior pituitary right hemisphere of cerebellum left adrenal cortex right lobe of liver right adrenal gland right adrenal cortex left ovary Top expressed in spermatocyte spermatid tail of embryo otic vesicle internal carotid artery external carotid artery granulocyte yolk sac saccule right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding nuclease activity 5'-3' exonuclease activity exonuclease activity mRNA binding RNA pyrophosphohydrolase activity hydrolase activity magnesium ion binding metal ion binding RNA binding Cellular component plasma membrane nucleus cytosol Biological process nuclear mRNA surveillance mRNA catabolic process RNA destabilization nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1797 112403 Ensembl ENSG00000204348 ENSG00000236765 ENSG00000224313 ENSG00000206346 ENSG00000225682 ENSG00000234798 ENSMUSG00000040482 UniProt O77932 O70348 RefSeq (mRNA) NM_005510 NM_001371205 NM_001371206 NM_001163770 NM_033613 RefSeq (protein) NP_005501 NP_001358134 NP_001358135 NP_001157242 NP_291091 Location (UCSC) Chr 6: 31.97 – 31.97 Mb Chr 17: 35.06 – 35.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The function of its protein product is unknown, but its ubiquitous expression and conservation in both simple and complex eukaryotes suggests that this may be a housekeeping gene.^[6]