DPF2

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.^[5][6]

DPF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IUF
Identifiers
Aliases	DPF2, REQ, UBID4, ubi-d4, double PHD fingers 2, CSS7, SMARCG2
External IDs	OMIM: 601671; MGI: 109529; HomoloGene: 21265; GeneCards: DPF2; OMA:DPF2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,333,852 bp[1] End 65,354,262 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 5,946,544 bp[2] End 5,963,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Achilles tendon ventricular zone body of uterus right ovary left ovary ganglionic eminence canal of the cervix muscle layer of sigmoid colon Top expressed in tail of embryo genital tubercle neural layer of retina ventricular zone otic vesicle internal carotid artery external carotid artery primitive streak epiblast lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription corepressor activity histone acetyltransferase activity histone binding H3K9me3 modified histone binding lysine-acetylated histone binding Cellular component nucleus nucleoplasm intracellular membrane-bounded organelle centrosome cytoplasm cytosol histone acetyltransferase complex nBAF complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated apoptotic signaling pathway apoptotic process negative regulation of transcription by RNA polymerase II chromatin organization nervous system development histone acetylation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of myeloid progenitor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5977 19708 Ensembl ENSG00000133884 ENSMUSG00000024826 UniProt Q92785 Q61103 RefSeq (mRNA) NM_006268 NM_001330308 NM_001291078 NM_011262 RefSeq (protein) NP_001317237 NP_006259 NP_006259.1 NP_001278007 NP_035392 Location (UCSC) Chr 11: 65.33 – 65.35 Mb Chr 19: 5.95 – 5.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors.^[6]