DPP10

Inactive dipeptidyl peptidase 10 is a protein that in humans is encoded by the DPP10 gene.^[5][6][7] Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[7]

DPP10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WJL
Identifiers
Aliases	DPP10, DPL2, DPPY, DPRP-3, DPRP3, dipeptidyl peptidase like 10
External IDs	OMIM: 608209; MGI: 2442409; HomoloGene: 41400; GeneCards: DPP10; OMA:DPP10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 114,442,299 bp[1] End 115,845,780 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 123,249,200 bp[2] End 124,773,776 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Brodmann area 23 prefrontal cortex dorsolateral prefrontal cortex Brodmann area 9 Brodmann area 46 cingulate gyrus anterior cingulate cortex primary visual cortex Amygdala Top expressed in substantia nigra piriform cortex prefrontal cortex Temporal Lobe Amygdala primary motor cortex cingulate gyrus lateral septal nucleus lobe of cerebellum medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel regulator activity serine-type peptidase activity dipeptidyl-peptidase activity transmembrane transporter binding Cellular component integral component of membrane plasma membrane membrane voltage-gated potassium channel complex Biological process protein localization to plasma membrane regulation of potassium ion transmembrane transport proteolysis positive regulation of protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57628 269109 Ensembl ENSG00000175497 ENSMUSG00000036815 UniProt Q8N608 Q6NXK7 RefSeq (mRNA) NM_001004360 NM_001178034 NM_001178036 NM_001178037 NM_020868 NM_001321905 NM_001321906 NM_001321907 NM_001321908 NM_001321909 NM_001321910 NM_001321911 NM_001321912 NM_001321913 NM_001321914 NM_001399849 NM_001399850 NM_001399851 NM_199021 RefSeq (protein) NP_001004360 NP_001171505 NP_001171507 NP_001171508 NP_001308834 NP_001308835 NP_001308836 NP_001308837 NP_001308838 NP_001308839 NP_001308840 NP_001308841 NP_001308842 NP_001308843 NP_065919 NP_950186 NP_001393353 NP_001393354 NP_001393355 Location (UCSC) Chr 2: 114.44 – 115.85 Mb Chr 1: 123.25 – 124.77 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties.^[7]

Clinical significance

Mutations in this gene have been associated with asthma^[7] and autism spectrum disorders.^[8]