DPP6

Dipeptidyl aminopeptidase-like protein 6 is a protein that in humans is encoded by the DPP6 gene.^[5][6]

DPP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XFD
Identifiers
Aliases	DPP6, DPPX, VF2, MRD33, DPL1, dipeptidyl peptidase like 6
External IDs	OMIM: 126141; MGI: 94921; HomoloGene: 22560; GeneCards: DPP6; OMA:DPP6 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q36.2 Start 153,887,097 bp[1] End 154,894,285 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B1|5 12.92 cM Start 27,022,201 bp[2] End 27,932,503 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 endothelial cell pons lateral nuclear group of thalamus primary visual cortex superior frontal gyrus postcentral gyrus entorhinal cortex Region I of hippocampus proper Top expressed in dentate gyrus of hippocampal formation granule cell cerebellar cortex habenula superior frontal gyrus primary visual cortex dorsomedial hypothalamic nucleus paraventricular nucleus of hypothalamus superior colliculus supraoptic nucleus ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function potassium channel regulator activity serine-type peptidase activity dipeptidyl-peptidase activity Cellular component integral component of membrane plasma membrane membrane voltage-gated potassium channel complex Biological process protein localization to plasma membrane regulation of potassium ion transmembrane transport proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1804 13483 Ensembl ENSG00000130226 ENSG00000282974 ENSMUSG00000061576 UniProt P42658 Q8IYG9 Q9Z218 RefSeq (mRNA) NM_001039350 NM_001290252 NM_001290253 NM_001936 NM_130797 NM_001136060 NM_001198886 NM_010075 NM_207282 RefSeq (protein) NP_001034439 NP_001277181 NP_001277182 NP_001927 NP_570629 NP_001351426 NP_001351427 NP_001351428 NP_001351429 NP_001351430 NP_001351431 NP_001277182.1 NP_570629.2 NP_001034439.1 NP_001277181.1 NP_001927.3 NP_570629.2 NP_001129532 NP_001185815 NP_034205 NP_997165 Location (UCSC) Chr 7: 153.89 – 154.89 Mb Chr 5: 27.02 – 27.93 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]