DPP8

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.^[5][6]

DPP8
Identifiers
Aliases	DPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8
External IDs	OMIM: 606819; MGI: 1921638; HomoloGene: 57098; GeneCards: DPP8; OMA:DPP8 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q22.31 Start 65,442,463 bp[1] End 65,517,704 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 C Start 64,939,696 bp[2] End 64,989,933 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell secondary oocyte nipple middle temporal gyrus Pons postcentral gyrus Skeletal muscle tissue of rectus abdominis lateral nuclear group of thalamus Brodmann area 23 biceps brachii Top expressed in spermatocyte muscle of thigh superior frontal gyrus aortic valve cerebellar cortex dentate gyrus of hippocampal formation granule cell ascending aorta temporal muscle inferior colliculi perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity aminopeptidase activity dipeptidyl-peptidase activity hydrolase activity Cellular component cytoplasm cytosol Biological process immune response proteolysis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54878 74388 Ensembl ENSG00000074603 ENSMUSG00000032393 UniProt Q6V1X1 Q80YA7 RefSeq (mRNA) NM_017743 NM_130434 NM_197960 NM_197961 NM_001320875 NM_001320876 NM_028906 NM_001401136 RefSeq (protein) NP_001307804 NP_001307805 NP_060213 NP_569118 NP_932064 NP_932065 NP_932064.1 NP_001307804.1 NP_083182 NP_001388065 Location (UCSC) Chr 15: 65.44 – 65.52 Mb Chr 9: 64.94 – 64.99 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.^[6] A relatively specific inhibitor of DPP8 and DPP9, Val-boroPro ^[7]-,^[8] leads to increased activation of the inflammasome though both NLRBP1 and CARD8 and can trigger pyroptosis.^[9]