DPPA3

Developmental pluripotency-associated protein 3 is a protein that in humans is encoded by the DPPA3 gene.^[3]

DPPA3
Identifiers
Aliases	DPPA3, STELLA, developmental pluripotency associated 3, Pgc7
External IDs	OMIM: 608408; HomoloGene: 138483; GeneCards: DPPA3; OMA:DPPA3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 7,711,433 bp[1] End 7,717,559 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle duodenum ventricular zone right testis blood muscle tissue left testis liver right ovary n/a More reference expression data BioGPS n/a
Gene ontology Molecular function methylated histone binding Cellular component male pronucleus cytoplasm nucleus female pronucleus Biological process multicellular organism development protection of DNA demethylation of female pronucleus negative regulation of DNA demethylation regulation of genetic imprinting chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 359787 n/a Ensembl ENSG00000187569 n/a UniProt Q6W0C5 n/a RefSeq (mRNA) NM_199286 n/a RefSeq (protein) NP_954980 n/a Location (UCSC) Chr 12: 7.71 – 7.72 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X.^[3]