DPYS

Dihydropyrimidinase is an enzyme that in humans is encoded by the DPYS gene.^[5][6]

DPYS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VR2
Identifiers
Aliases	DPYS, dihydropyrimidinase, DHP, DHPase
External IDs	OMIM: 613326; MGI: 1928679; HomoloGene: 20359; GeneCards: DPYS; OMA:DPYS - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 104,330,324 bp[1] End 104,467,055 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 39,631,883 bp[2] End 39,720,866 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule glomerulus metanephric glomerulus human kidney right adrenal cortex left adrenal cortex testicle gonad mucosa of paranasal sinus Top expressed in left lobe of liver primary oocyte proximal tubule right kidney respiratory epithelium olfactory epithelium zygote secondary oocyte embryo spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function amino acid binding zinc ion binding metal ion binding dihydropyrimidinase activity phosphoprotein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds thymine binding uracil binding hydrolase activity Cellular component cytoplasm cytosol extracellular exosome Biological process beta-alanine metabolic process uracil catabolic process pyrimidine nucleoside catabolic process uracil metabolic process pyrimidine nucleobase catabolic process protein homooligomerization protein homotetramerization thymine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1807 64705 Ensembl ENSG00000147647 ENSMUSG00000022304 UniProt Q14117 Q9EQF5 RefSeq (mRNA) NM_001385 NM_001164466 NM_022722 RefSeq (protein) NP_001376 NP_001157938 NP_073559 Location (UCSC) Chr 8: 104.33 – 104.47 Mb Chr 15: 39.63 – 39.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dihydropyrimidinase catalyzes the conversion of 5,6-dihydrouracil to 3-ureidopropionate in pyrimidine metabolism. Dihydropyrimidinase is expressed at a high level in liver and kidney as a major 2.5-kb transcript and a minor 3.8-kb transcript. Defects in the DPYS gene are linked to dihydropyrimidinuria.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".