DPYSL2

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.^[5][6]

DPYSL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2GSE, 2VM8
Identifiers
Aliases	DPYSL2, CRMP-2, CRMP2, DHPRP2, DRP-2, DRP2, N2A3, ULIP-2, ULIP2, dihydropyrimidinase like 2
External IDs	OMIM: 602463; MGI: 1349763; HomoloGene: 74392; GeneCards: DPYSL2; OMA:DPYSL2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 26,514,031 bp[1] End 26,658,178 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.6 cM Start 67,040,313 bp[2] End 67,106,137 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve pars reticulata subthalamic nucleus pars compacta superior vestibular nucleus external globus pallidus Pons cerebellar vermis lateral nuclear group of thalamus paraflocculus of cerebellum Top expressed in paraventricular nucleus of hypothalamus globus pallidus anterior amygdaloid area habenula medial geniculate nucleus dorsomedial hypothalamic nucleus ventral tegmental area medial dorsal nucleus anterior horn of spinal cord subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding dihydropyrimidinase activity protein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity identical protein binding Cellular component cytoplasm cytosol membrane extracellular exosome microtubule cytoskeleton plasma membrane Biological process regulation of neuron differentiation cell differentiation endocytosis regulation of axon extension nervous system development multicellular organism development brain development cytoskeleton organization nucleobase-containing compound metabolic process signal transduction axon guidance pyrimidine nucleobase catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1808 12934 Ensembl ENSG00000092964 ENSMUSG00000022048 UniProt Q16555 O08553 RefSeq (mRNA) NM_001386 NM_001197293 NM_001244604 NM_009955 NM_001378767 RefSeq (protein) NP_001184222 NP_001231533 NP_001377 NP_034085 NP_001365696 Location (UCSC) Chr 8: 26.51 – 26.66 Mb Chr 14: 67.04 – 67.11 Mb PubMed search [3] [4]
Wikidata
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Interactions

DPYSL2 has been shown to interact with CRMP1,^[7] Adaptor-related protein complex 2, alpha 1^[8] and NUMB.^[8]