DPYSL3

Dihydropyrimidinase-related protein 3 is an enzyme that in humans is encoded by the DPYSL3 gene.^[5][6][7] A recent bioinformatics study suggested that the DPYSL3 gene might have a prognostic role in neuroblastoma.^[8]

DPYSL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BKN, 4CNS, 4CNT, 4CNU
Identifiers
Aliases	DPYSL3, CRMP-4, CRMP4, DRP-3, DRP3, LCRMP, ULIP, ULIP-1, dihydropyrimidinase like 3
External IDs	OMIM: 601168; MGI: 1349762; HomoloGene: 20361; GeneCards: DPYSL3; OMA:DPYSL3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q32 Start 147,390,808 bp[1] End 147,510,068 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B3 Start 43,454,049 bp[2] End 43,571,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone saphenous vein gastric mucosa tail of epididymis right coronary artery tibial arteries ascending aorta urethra optic nerve Top expressed in superior cervical ganglion Rostral migratory stream barrel cortex ganglionic eminence seminiferous tubule optic nerve medial ganglionic eminence neural tube sexually immature organism pineal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding protein binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds chondroitin sulfate binding hydrolase activity filamin binding Cellular component cytoplasm cell body filamentous actin cytosol cell projection exocytic vesicle growth cone lamellipodium extracellular space synapse Biological process negative regulation of neuron projection development regulation of cell migration regulation of neuron projection development neuron development actin filament bundle assembly negative regulation of cell migration response to axon injury actin crosslink formation positive regulation of neuron projection development protein homooligomerization positive regulation of filopodium assembly cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1809 22240 Ensembl ENSG00000113657 ENSMUSG00000024501 UniProt Q14195 Q62188 RefSeq (mRNA) NM_001197294 NM_001387 NM_001136086 NM_001291455 NM_009468 RefSeq (protein) NP_001184223 NP_001378 NP_001129558 NP_001278384 NP_033494 Location (UCSC) Chr 5: 147.39 – 147.51 Mb Chr 18: 43.45 – 43.57 Mb PubMed search [3] [4]
Wikidata
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