DPYSL5

Dihydropyrimidinase-related protein 5 is an enzyme that in humans is encoded by the DPYSL5 gene.^[5][6][7]

DPYSL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4B90, 4B91, 4B92
Identifiers
Aliases	DPYSL5, CRAM, CRMP-5, CRMP5, Ulip6, dihydropyrimidinase like 5, CV2, RTSC4
External IDs	OMIM: 608383; MGI: 1929772; HomoloGene: 41347; GeneCards: DPYSL5; OMA:DPYSL5 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 26,847,747 bp[1] End 26,950,351 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 30,868,908 bp[2] End 30,956,719 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone C1 segment nucleus accumbens putamen substantia nigra caudate nucleus corpus callosum hypothalamus inferior ganglion of vagus nerve Top expressed in tail of embryo ganglionic eminence ventricular zone lumbar spinal ganglion neural layer of retina Rostral migratory stream superior cervical ganglion genital tubercle epiblast seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding protein binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds dihydropyrimidinase activity Cellular component cytoplasm cytosol soma dendrite Biological process signal transduction nervous system development axon guidance pyrimidine nucleobase catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56896 65254 Ensembl ENSG00000157851 ENSMUSG00000029168 UniProt Q9BPU6 Q9EQF6 RefSeq (mRNA) NM_020134 NM_001253723 NM_001253724 NM_023047 NM_001356948 NM_001356949 RefSeq (protein) NP_001240652 NP_001240653 NP_064519 NP_075534 NP_001343877 NP_001343878 Location (UCSC) Chr 2: 26.85 – 26.95 Mb Chr 5: 30.87 – 30.96 Mb PubMed search [3] [4]
Wikidata
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Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.[supplied by OMIM]^[7]