DRG2

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.^[5][6][7]

DRG2
Identifiers
Aliases	DRG2, developmentally regulated GTP binding protein 2
External IDs	OMIM: 602986; MGI: 1342307; HomoloGene: 1061; GeneCards: DRG2; OMA:DRG2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p11.2 Start 18,087,892 bp[1] End 18,107,970 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B2|11 37.81 cM Start 60,345,417 bp[2] End 60,359,580 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right lobe of liver anterior pituitary apex of heart body of uterus gastrocnemius muscle right ovary right lobe of thyroid gland left ovary canal of the cervix Top expressed in otic vesicle morula neural layer of retina internal carotid artery otic placode external carotid artery saccule tail of embryo epiblast ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding RNA binding GTPase activity hydrolase activity metal ion binding Cellular component membrane mitochondrion intracellular membrane-bounded organelle nucleoplasm cytoplasm cytosol nucleus Biological process signal transduction cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1819 13495 Ensembl ENSG00000108591 ENSMUSG00000020537 UniProt P55039 Q9QXB9 RefSeq (mRNA) NM_001388 NM_001330144 NM_021354 RefSeq (protein) NP_001317073 NP_001379 NP_067329 Location (UCSC) Chr 17: 18.09 – 18.11 Mb Chr 11: 60.35 – 60.36 Mb PubMed search [3] [4]
Wikidata
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The DRG2 gene encodes the developmentally regulated GTP-binding protein 2, a name derived from the fact that it shares significant similarity to known GTP-binding proteins. DRG2 was identified because it is expressed in normal fibroblasts but not in SV40-transformed fibroblasts. Read-through transcripts containing this gene and a downstream gene have been identified, but they are not thought to encode a fusion protein. This gene is located within the Smith-Magenis syndrome region on chromosome 17.^[7]