DTL (gene)

Denticleless protein homolog is a protein that in humans is encoded by the DTL gene.^[5][6]

DTL
Identifiers
Aliases	DTL, CDT2, DCAF2, L2RAMP, denticleless E3 ubiquitin protein ligase homolog
External IDs	OMIM: 610617; MGI: 1924093; HomoloGene: 32313; GeneCards: DTL; OMA:DTL - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.3 Start 212,035,553 bp[1] End 212,107,400 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H6 Start 191,269,468 bp[2] End 191,307,656 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte trabecular bone embryo testicle ventricular zone bone marrow ganglionic eminence gonad bone marrow cell sperm Top expressed in mandibular prominence maxillary prominence zygote secondary oocyte ureter lumbar spinal ganglion primitive streak primary oocyte hand fetal liver hematopoietic progenitor cell More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin-protein transferase activity protein binding Cellular component centrosome nuclear membrane membrane chromosome microtubule organizing center nucleolus Cul4A-RING E3 ubiquitin ligase complex Cul4B-RING E3 ubiquitin ligase complex cytoskeleton nucleus nucleoplasm cytoplasm cytosol Cul4-RING E3 ubiquitin ligase complex Biological process ubiquitin-dependent protein catabolic process protein polyubiquitination protein monoubiquitination regulation of cell cycle DNA replication protein ubiquitination response to UV translesion synthesis post-translational protein modification cellular response to DNA damage stimulus positive regulation of G2/M transition of mitotic cell cycle positive regulation of protein catabolic process mitotic G2 DNA damage checkpoint signaling rhythmic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51514 76843 Ensembl ENSG00000143476 ENSMUSG00000037474 UniProt Q9NZJ0 Q3TLR7 RefSeq (mRNA) NM_001286229 NM_001286230 NM_016448 NM_029766 NM_001305233 RefSeq (protein) NP_001273158 NP_001273159 NP_057532 NP_001292162 NP_084042 Location (UCSC) Chr 1: 212.04 – 212.11 Mb Chr 1: 191.27 – 191.31 Mb PubMed search [3] [4]
Wikidata
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Interactions

DTL (gene) has been shown to interact with P21.^[7]