DTX2

Protein deltex-2 also known as E3 ubiquitin-protein ligase DTX2 is an enzyme that in humans is encoded by the DTX2 gene.^[5]

DTX2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1V87
Identifiers
Aliases	DTX2, RNF58, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2
External IDs	OMIM: 613141; MGI: 1921448; HomoloGene: 56904; GeneCards: DTX2; OMA:DTX2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q11.23 Start 76,461,676 bp[1] End 76,505,995 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G2 Start 136,023,654 bp[2] End 136,061,726 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon olfactory zone of nasal mucosa sural nerve right testis minor salivary glands left testis blood skin of leg skin of abdomen vagina Top expressed in secondary oocyte primary oocyte zygote Rostral migratory stream condyle internal carotid artery fossa external carotid artery hair follicle motor neuron More reference expression data BioGPS More reference expression data
Gene ontology Molecular function zinc ion binding protein binding metal ion binding transferase activity Cellular component cytoplasm nuclear membrane nucleus nucleoplasm Biological process Notch signaling pathway protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 113878 74198 Ensembl ENSG00000282379 ENSG00000091073 ENSMUSG00000004947 UniProt Q86UW9 Q8R3P2 RefSeq (mRNA) NM_001102594 NM_001102595 NM_001102596 NM_020892 NM_001256096 NM_001256097 NM_001256098 NM_023742 RefSeq (protein) NP_001096064 NP_001096065 NP_001096066 NP_065943 NP_001243025 NP_001243026 NP_001243027 NP_076231 Location (UCSC) Chr 7: 76.46 – 76.51 Mb Chr 5: 136.02 – 136.06 Mb PubMed search [3] [4]
Wikidata
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DTX2 functions as a ubiquitin E3 ligase in conjunction with the E2 enzyme UBCH5A.^[6]