DUSP1

Dual specificity protein phosphatase 1 is an enzyme that in humans is encoded by the DUSP1 gene.^[5][6]

DUSP1
Identifiers
Aliases	DUSP1, CL100, HVH1, MKP-1, MKP1, PTPN10, dual specificity phosphatase 1
External IDs	OMIM: 600714; MGI: 105120; HomoloGene: 3254; GeneCards: DUSP1; OMA:DUSP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.1 Start 172,768,096 bp[1] End 172,771,195 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 13.28 cM Start 26,724,564 bp[2] End 26,781,102 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava nipple urethra mucosa of paranasal sinus skin of thigh mucosa of urinary bladder cardia lower lobe of lung saphenous vein trachea Top expressed in granulocyte stroma of bone marrow endothelial cell of lymphatic vessel right lung right lung lobe plantaris muscle ascending aorta soleus muscle ankle left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine/threonine phosphatase activity phosphatase activity protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity hydrolase activity protein tyrosine/serine/threonine phosphatase activity growth factor binding protein serine/threonine phosphatase activity mitogen-activated protein kinase binding Cellular component nucleus cytoplasm Biological process positive regulation of apoptotic process response to estradiol response to retinoic acid response to oxidative stress negative regulation of meiotic cell cycle response to calcium ion response to hydrogen peroxide response to testosterone protein dephosphorylation intracellular signal transduction negative regulation of MAP kinase activity negative regulation of MAPK cascade peptidyl-threonine dephosphorylation cell cycle response to light stimulus negative regulation of DNA biosynthetic process negative regulation of ERK1 and ERK2 cascade cellular response to hormone stimulus dephosphorylation regulation of apoptotic process response to glucocorticoid endoderm formation response to organic substance regulation of mitotic cell cycle spindle assembly checkpoint negative regulation of apoptotic process response to cAMP negative regulation of cell population proliferation peptidyl-tyrosine dephosphorylation peptidyl-serine dephosphorylation negative regulation of cell adhesion negative regulation of monocyte chemotaxis negative regulation of p38MAPK cascade cellular response to chemokine Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1843 19252 Ensembl ENSG00000120129 ENSMUSG00000024190 UniProt P28562 P28563 RefSeq (mRNA) NM_004417 NM_013642 RefSeq (protein) NP_004408 NP_038670 Location (UCSC) Chr 5: 172.77 – 172.77 Mb Chr 17: 26.72 – 26.78 Mb PubMed search [3] [4]
Wikidata
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Function

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.^[7]

Interactions

DUSP1 has been shown to interact with MAPK14,^[8][9] MAPK1^[9][10] and MAPK8.^[9]