DUSP5

Dual specificity protein phosphatase 5 is an enzyme that in humans is encoded by the DUSP5 gene.^[5][6]

DUSP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2G6Z
Identifiers
Aliases	DUSP5, DUSP, HVH3, dual specificity phosphatase 5
External IDs	OMIM: 603069; MGI: 2685183; HomoloGene: 3256; GeneCards: DUSP5; OMA:DUSP5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 110,497,907 bp[1] End 110,511,533 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 53,517,540 bp[2] End 53,530,862 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of urinary bladder mucosa of pharynx gallbladder testicle epithelium of esophagus islet of Langerhans secondary oocyte cartilage tissue vena cava palpebral conjunctiva Top expressed in lumbar spinal ganglion lobe of cerebellum cerebellar vermis parotid gland granulocyte mesenteric lymph nodes decidua lacrimal gland islet of Langerhans thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity protein binding protein tyrosine phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity hydrolase activity phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component nucleoplasm nucleus cytoplasm Biological process protein dephosphorylation MAPK cascade endoderm formation peptidyl-tyrosine dephosphorylation dephosphorylation peptidyl-threonine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1847 240672 Ensembl ENSG00000138166 ENSMUSG00000034765 UniProt Q16690 Q1HL35 RefSeq (mRNA) NM_004419 NM_001085390 RefSeq (protein) NP_004410 NP_001078859 Location (UCSC) Chr 10: 110.5 – 110.51 Mb Chr 19: 53.52 – 53.53 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1/2, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus.^[6]