DVL2

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.^[5][6]

DVL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2REY, 3CBX, 3CBY, 3CBZ, 3CC0, 4WIP
Identifiers
Aliases	DVL2, dishevelled segment polarity protein 2
External IDs	OMIM: 602151; MGI: 106613; HomoloGene: 20927; GeneCards: DVL2; OMA:DVL2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,225,342 bp[1] End 7,234,517 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.96 cM Start 69,891,421 bp[2] End 69,903,127 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone stromal cell of endometrium left ovary ectocervix right ovary body of uterus right hemisphere of cerebellum canal of the cervix anterior pituitary ganglionic eminence Top expressed in yolk sac ventricular zone granulocyte epiblast superior frontal gyrus neural layer of retina spermatocyte genital tubercle tail of embryo dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity protein domain specific binding frizzled binding protein self-association protein binding identical protein binding protein kinase binding Cellular component membrane clathrin-coated endocytic vesicle plasma membrane apical part of cell clathrin-coated vesicle cytoplasm cytoplasmic vesicle nucleus cytosol nucleoplasm aggresome lateral plasma membrane nuclear body Biological process non-canonical Wnt signaling pathway positive regulation of protein phosphorylation intracellular signal transduction positive regulation of protein tyrosine kinase activity heart morphogenesis canonical Wnt signaling pathway involved in regulation of cell proliferation positive regulation of DNA-binding transcription factor activity transcription by RNA polymerase II hippo signaling positive regulation of transcription, DNA-templated multicellular organism development positive regulation of GTPase activity protein complex oligomerization cochlea morphogenesis convergent extension involved in neural plate elongation negative regulation of canonical Wnt signaling pathway segmentation convergent extension involved in organogenesis positive regulation of canonical Wnt signaling pathway neural tube closure heart development Wnt signaling pathway outflow tract morphogenesis canonical Wnt signaling pathway segment specification positive regulation of JUN kinase activity planar cell polarity pathway involved in neural tube closure Wnt signaling pathway, planar cell polarity pathway beta-catenin destruction complex disassembly membrane organization positive regulation of neuron projection arborization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1856 13543 Ensembl ENSG00000004975 ENSMUSG00000020888 UniProt O14641 Q60838 RefSeq (mRNA) NM_004422 NM_007888 RefSeq (protein) NP_004413 NP_031914 Location (UCSC) Chr 17: 7.23 – 7.23 Mb Chr 11: 69.89 – 69.9 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.^[6]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,^[7] DAB2^[8] and Arrestin beta 1.^[9]

See also

• Dishevelled