DYNLT1

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene.^[5][6][7]

DYNLT1
Identifiers
Aliases	DYNLT1, CW-1, TCTEL1, tctex-1, dynein light chain Tctex-type 1, TCTEX1
External IDs	OMIM: 601554; MGI: 98643; HomoloGene: 4754; GeneCards: DYNLT1; OMA:DYNLT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q25.3 Start 158,636,474 bp[1] End 158,644,743 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A1|17 3.97 cM Start 6,697,511 bp[2] End 6,703,695 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell epithelium of nasopharynx olfactory zone of nasal mucosa palpebral conjunctiva nasal epithelium oral cavity ganglionic eminence islet of Langerhans jejunal mucosa mucosa of paranasal sinus Top expressed in spermatid spermatocyte neural tube mesencephalon lens testicle islet of Langerhans granulocyte epiblast urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding cytoskeletal motor activity protein C-terminus binding Cellular component cytoplasm Golgi apparatus secretory vesicle spindle dynein complex cytoplasmic microtubule microtubule cytoskeleton host cell extracellular region cytoplasmic dynein complex secretory granule lumen ficolin-1-rich granule lumen mitochondrion lamellipodium soma axonal growth cone Biological process intracellular transport of viral protein in host cell regulation of G protein-coupled receptor signaling pathway negative regulation of neurogenesis nervous system development cell division establishment of mitotic spindle orientation microtubule-dependent intracellular transport of viral material towards nucleus viral entry into host cell cell cycle viral process transport of viral material towards nucleus neutrophil degranulation positive regulation of neuron projection development dendrite development positive regulation of Rac protein signal transduction negative regulation of mitochondrial membrane permeability regulation of GTPase activity neuron projection morphogenesis regulation of cytoskeleton organization negative regulation of cell death axon development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6993 21648 Ensembl ENSG00000146425 ENSMUSG00000096255 UniProt P63172 P51807 RefSeq (mRNA) NM_006519 NM_001291602 NM_001291603 NM_009342 RefSeq (protein) NP_001278531 NP_001278532 NP_006510 NP_001160099 NP_001186877 NP_001160102 NP_001160101 NP_033368 Location (UCSC) Chr 6: 158.64 – 158.64 Mb Chr 17: 6.7 – 6.7 Mb PubMed search [3] [4]
Wikidata
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Cytoplasmic dynein is the major motor protein complex responsible for minus-end, microtubule-based motile processes. Each dynein complex consists of 2 heavy chains that have ATPase and motor activities, plus a group of accessory polypeptides. TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM]^[7]

In cancer patients, DYNLT1 expression has been linked to both higher and lower survival rates, depending on cancer type.^[8]