DYNLT3

Dynein, light chain, Tctex-type 3, also known as DYNLT3, is a protein which in humans is encoded by the DYNLT3 gene.^[5][6]

DYNLT3
Identifiers
Aliases	DYNLT3, RP3, TCTE1L, TCTEX1L, dynein light chain Tctex-type 3
External IDs	OMIM: 300302; MGI: 1914367; HomoloGene: 21304; GeneCards: DYNLT3; OMA:DYNLT3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xp11.4 Start 37,836,757 bp[1] End 37,847,571 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A1.1 Start 9,520,506 bp[2] End 9,529,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums gingival epithelium pons dorsal motor nucleus of vagus nerve pars compacta Brodmann area 23 lateral nuclear group of thalamus optic nerve oral cavity glomerulus Top expressed in Epithelium of choroid plexus transitional epithelium of urinary bladder seminal vesicula deep cerebellar nuclei medial vestibular nucleus retinal pigment epithelium lateral geniculate nucleus epithelium of lens conjunctival fornix facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity protein binding identical protein binding Cellular component cytoplasm kinetochore chromosome dynein complex cytoplasmic dynein complex microtubule chromosome, centromeric region cytoskeleton nucleus mitotic spindle astral microtubule Biological process cell cycle regulation of mitotic cell cycle cell division positive regulation of mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6990 67117 Ensembl ENSG00000165169 ENSMUSG00000031176 UniProt P51808 P56387 RefSeq (mRNA) NM_006520 NM_025975 RefSeq (protein) NP_006511 NP_080251 Location (UCSC) Chr X: 37.84 – 37.85 Mb Chr X: 9.52 – 9.53 Mb PubMed search [3] [4]
Wikidata
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Function

DYNLT3 is a member of the dynein motor protein family. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase.^[7] DYNLT3 can also function as a transcription regulator of Bcl-2 gene through binding to SATB1 in a dynein-independent manner.^[8]

Interactions

DYNLT3 has been shown to interact with VDAC1.^[9]