Decoy receptor 1

Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily.^[3][4][5]

TNFRSF10C
Identifiers
Aliases	TNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID, tumor necrosis factor receptor superfamily member 10c, TNF receptor superfamily member 10c
External IDs	OMIM: 603613; HomoloGene: 48244; GeneCards: TNFRSF10C; OMA:TNFRSF10C - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 23,102,921 bp[1] End 23,117,445 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte testicle periodontal fiber bone marrow gonad monocyte spleen gallbladder bone marrow cells n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity TRAIL binding Cellular component anchored component of membrane integral component of plasma membrane membrane plasma membrane cell surface Biological process multicellular organism development response to lipopolysaccharide inflammatory response regulation of cell population proliferation immune response signal transduction apoptotic process tumor necrosis factor-mediated signaling pathway apoptotic signaling pathway regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TRAIL-activated apoptotic signaling pathway positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8794 n/a Ensembl ENSG00000173535 n/a UniProt O14798 n/a RefSeq (mRNA) NM_003841 n/a RefSeq (protein) NP_003832 n/a Location (UCSC) Chr 8: 23.1 – 23.12 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.^[5]