KIAA1967

Not to be confused with Deleted in Bladder Cancer 1 (DBC1).

KIAA1967, also known as Deleted in Breast Cancer 1, is a protein which in humans is encoded by the KIAA1967 gene.^[5][6][7]

CCAR2
Identifiers
Aliases	CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
External IDs	OMIM: 607359; MGI: 2444228; HomoloGene: 10910; GeneCards: CCAR2; OMA:CCAR2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.3 Start 22,604,757 bp[1] End 22,620,964 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D2 Start 70,375,613 bp[2] End 70,391,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence right uterine tube right testis left testis granulocyte skin of leg cerebellar hemisphere right hemisphere of cerebellum appendix Top expressed in ventricular zone spermatocyte neural layer of retina dentate gyrus of hippocampal formation granule cell renal corpuscle medullary collecting duct neural tube ganglionic eminence superior frontal gyrus primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II complex binding enzyme inhibitor activity protein binding enzyme binding RNA binding nuclear receptor coactivator activity Cellular component cytoplasm nucleoplasm DBIRD complex mitochondrial matrix spliceosomal complex nucleus Biological process mitochondrial fragmentation involved in apoptotic process negative regulation of catalytic activity regulation of transcription, DNA-templated regulation of protein stability positive regulation of DNA damage checkpoint rhythmic process positive regulation of canonical Wnt signaling pathway mRNA processing regulation of DNA-templated transcription, elongation regulation of protein deacetylation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Wnt signaling pathway transcription, DNA-templated cellular response to DNA damage stimulus regulation of circadian rhythm negative regulation of cell growth RNA splicing negative regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of apoptotic process regulation of cellular response to heat cell cycle negative regulation of transcription, DNA-templated response to UV apoptotic process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57805 219158 Ensembl ENSG00000158941 ENSMUSG00000033712 UniProt Q8N163 Q8VDP4 RefSeq (mRNA) NM_021174 NM_199205 NM_001363068 NM_001363069 NM_001393997 NM_146055 RefSeq (protein) NP_066997 NP_001349997 NP_001349998 NP_666167 Location (UCSC) Chr 8: 22.6 – 22.62 Mb Chr 14: 70.38 – 70.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Recent studies show that DBC1 is an inhibitor of the sirtuin-type deacetylase, SIRT1, which deacetylates histones and p53.^[8][9] DBC1 is likely to regulate the activity of SIRT1 or related deacetylases by sensing the soluble products or substrates of the NAD-dependent deacetylation reaction.^[10]