Deleted in lung and esophageal cancer 1

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. ^[5]

DLEC1
Identifiers
Aliases	DLEC1, CFAP81, DLC1, F56, DLC-1, deleted in lung and esophageal cancer 1, cilia and flagella associated protein, DLEC1 cilia and flagella associated protein, FAP81
External IDs	OMIM: 604050; MGI: 2443671; HomoloGene: 84733; GeneCards: DLEC1; OMA:DLEC1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,039,205 bp[1] End 38,124,025 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 118,931,546 bp[2] End 118,977,314 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube epithelium of bronchus bronchial epithelial cell olfactory zone of nasal mucosa mucosa of paranasal sinus nasal epithelium left testis right testis caput epididymis epithelium of nasopharynx Top expressed in spermatid renal cortex spermatocyte testicle proximal tubule human kidney right kidney ovary hypothalamus zygote More reference expression data BioGPS n/a
Gene ontology Molecular function molecular function Cellular component cytoplasm cytosol Biological process negative regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9940 320256 Ensembl ENSG00000008226 ENSMUSG00000038060 UniProt Q9Y238 Q32W76 Q8BLA1 RefSeq (mRNA) NM_007335 NM_007336 NM_007337 NM_007338 NM_001321153 NM_177117 NM_001368820 NM_001368821 RefSeq (protein) NP_001308082 NP_031361 NP_031363 n/a Location (UCSC) Chr 3: 38.04 – 38.12 Mb Chr 9: 118.93 – 118.98 Mb PubMed search [3] [4]
Wikidata
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Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].