Dendrocyte expressed seven transmembrane protein

Dendrocyte expressed seven transmembrane protein is a protein that in humans is encoded by the DCSTAMP gene.^[5]

DCSTAMP
Identifiers
Aliases	DCSTAMP, FIND, TM7SF4, hDC-STAMP, dendrocyte expressed seven transmembrane protein
External IDs	OMIM: 605933; MGI: 1923016; HomoloGene: 12769; GeneCards: DCSTAMP; OMA:DCSTAMP - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 104,339,087 bp[1] End 104,356,689 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.1 Start 39,609,326 bp[2] End 39,624,334 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium amygdala right lung upper lobe of left lung islet of Langerhans tibia right uterine tube Brodmann area 9 amniotic fluid right lobe of liver Top expressed in body of femur blastocyst cochlea submandibular gland adrenal gland pituitary gland lens lip islet of Langerhans respiratory system More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane endosome endoplasmic reticulum membrane membrane plasma membrane cell surface integral component of endoplasmic reticulum membrane endoplasmic reticulum endosome membrane endoplasmic reticulum-Golgi intermediate compartment membrane Biological process cellular response to interleukin-4 cell differentiation immune system process osteoclast differentiation cellular response to tumor necrosis factor membrane fusion myeloid dendritic cell differentiation positive regulation of bone resorption positive regulation of macrophage fusion cellular response to macrophage colony-stimulating factor stimulus osteoclast fusion negative regulation of cell growth positive regulation of monocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81501 75766 Ensembl ENSG00000164935 ENSMUSG00000022303 UniProt Q9H295 Q7TNJ0 RefSeq (mRNA) NM_001257317 NM_030788 NM_001289506 NM_001289508 NM_001289512 NM_001289513 NM_029422 RefSeq (protein) NP_001244246 NP_110415 NP_001276435 NP_001276437 NP_001276441 NP_001276442 NP_083698 Location (UCSC) Chr 8: 104.34 – 104.36 Mb Chr 15: 39.61 – 39.62 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012].