Dihydroorotase

Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.^[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.^[3]

carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Dihydroorotase (fragment) dimer, Human
Identifiers
Symbol	CAD
NCBI gene	790
HGNC	1424
OMIM	114010
RefSeq	NM_004341
UniProt	P27708
Other data
EC number	3.5.2.3
Locus	Chr. 2 p22-p21
Search for Structures Swiss-model Domains InterPro

See also

• Pyrimidine biosynthesis