Diphenylbutylpiperidine

Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica.^[1][2]

Base chemical structure of the diphenylbutylpiperidine antipsychotics.

They include:

• Clopimozide (R-29,764)
• Fluspirilene (Redeptin)
• Penfluridol (Semap, Micefal, Longoperidol)
• Pimozide (Orap)

A closely related antipsychotic, amperozide, has an additional nitrogen atom in the heterocyclic ring and is classified as a diphenylbutylpiperazine.^[3]

Other diphenylbutylpiperazines include lidoflazine, PR-000608, FG5865, FG-5893, mioflazine & difluanazine.^[4][5]