Dopachrome tautomerase

Dopachrome tautomerase (dopachrome delta-isomerase, tyrosinase-related protein 2), also known as DCT, is a human gene.^[5] Its expression is regulated by the microphthalmia-associated transcription factor (MITF).^[6][7]

DCT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HX1
Identifiers
Aliases	DCT, TRP-2, TYRP2, dopachrome tautomerase, OCA8
External IDs	OMIM: 191275; MGI: 102563; HomoloGene: 1447; GeneCards: DCT; OMA:DCT - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q32.1 Start 94,436,811 bp[1] End 94,479,682 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 E4|14 61.6 cM Start 118,250,202 bp[2] End 118,289,656 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh skin of arm secondary oocyte nipple skin of hip vulva human penis retinal pigment epithelium testicle skin of abdomen Top expressed in iris ciliary body stria vascularis hair follicle retinal pigment epithelium utricle epithelium of lens corneal stroma skin of back left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function isomerase activity metal ion binding oxidoreductase activity copper ion binding dopachrome isomerase activity Cellular component cytoplasm integral component of membrane cytosol membrane melanosome melanosome membrane Biological process positive regulation of neuroblast proliferation melanin biosynthetic process cell development ventricular zone neuroblast division melanin biosynthetic process from tyrosine epidermis development developmental pigmentation pigmentation metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1638 13190 Ensembl ENSG00000080166 ENSMUSG00000022129 UniProt P40126 P29812 RefSeq (mRNA) NM_001129889 NM_001922 NM_001322182 NM_001322183 NM_001322184 NM_001322185 NM_001322186 NM_010024 RefSeq (protein) NP_001123361 NP_001309111 NP_001309112 NP_001309113 NP_001309114 NP_001309115 NP_001913 NP_034154 Location (UCSC) Chr 13: 94.44 – 94.48 Mb Chr 14: 118.25 – 118.29 Mb PubMed search [3] [4]
Wikidata
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See also

• Tyrosinase-related protein 1 (TYRP1)
• Dopachrome, a cyclization product of L-DOPA and is an intermediate in the biosynthesis of melanin.