Drebrin-like

Drebrin-like protein is a protein that in humans is encoded by the DBNL gene.^[5][6]

DBNL
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X67
Identifiers
Aliases	DBNL, ABP1, HIP-55, HIP55, SH3P7, Drebrin-like, drebrin like
External IDs	OMIM: 610106; MGI: 700006; HomoloGene: 8468; GeneCards: DBNL; OMA:DBNL - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p13 Start 44,044,640 bp[1] End 44,069,456 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 3.87 cM Start 5,738,488 bp[2] End 5,750,962 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte appendix spleen mucosa of transverse colon stromal cell of endometrium gallbladder left coronary artery ectocervix right coronary artery Top expressed in Ileal epithelium granulocyte lens lip genital tubercle esophagus mesenteric lymph nodes transitional epithelium of urinary bladder neural tube dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding protein C-terminus binding protein binding enzyme activator activity actin filament binding actin binding cadherin binding Cellular component endosome Golgi apparatus cell projection postsynaptic density membrane Golgi membrane plasma membrane synapse intracellular anatomical structure cell junction dendrite early endosome clathrin-coated vesicle membrane extracellular exosome cytoskeleton cytoplasmic vesicle podosome lamellipodium cytoplasm ruffle cell cortex cytosol extracellular region secretory granule lumen tertiary granule lumen ficolin-1-rich granule lumen Biological process endocytosis adaptive immune response immune system process synapse assembly neuron projection morphogenesis podosome assembly Rac protein signal transduction neutrophil degranulation receptor-mediated endocytosis ruffle assembly transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 28988 13169 Ensembl ENSG00000136279 ENSMUSG00000020476 UniProt Q9UJU6 Q62418 RefSeq (mRNA) NM_001014436 NM_001122956 NM_001284313 NM_001284315 NM_014063 NM_001362723 NM_001146308 NM_001146309 NM_013810 RefSeq (protein) NP_001014436 NP_001116428 NP_001271242 NP_001271244 NP_054782 NP_001349652 NP_001139780 NP_001139781 NP_038838 Location (UCSC) Chr 7: 44.04 – 44.07 Mb Chr 11: 5.74 – 5.75 Mb PubMed search [3] [4]
Wikidata
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Interactions

Drebrin-like has been shown to interact with Cyclin-dependent kinase 4,^[7] MAP4K1^[8] and ZAP-70.^[9]