Dual-specificity kinase

In biochemistry, a dual-specificity kinase (EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase.

Dual-specificity kinase
Identifiers
EC no.	2.7.12.1
CAS no.	134549-83-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:

• ADK1 (Arabidopsis dual specificity kinase 1)
• CLK1, CLK2, CLK3, CLK4
• DSTYK
• DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4
• Mps1p
• TESK1, TESK2
• TTK

The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).