Dynamin superfamily

Dynamin Superfamily Protein (DSP) is a protein superfamily includes classical dynamins, GBPs, Mx proteins, OPA1, mitofusins in Eukaryote, and bacterial dynamin-like proteins (BDLPs) in Prokaryote.^[1] DSPs mediate eukaryotic membrane fusion and fission necessary for endocytosis, organelle biogenesis and maintenance, Mitochondrial fusion and fission, as well as for prokaryotic cytokinesis.^[2]

Dynamin superfamily
Identifiers
Symbol	DSP
InterPro	IPR022812

Structure

All DSPs have two common domains: a GTPase domain and an elongated α-helical bundle domain.^[2] Except GBP1, other DSPs have additional domains, like dynamin has a pleckstrin homology domain.^[3]