MFN1

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.^[5][6][7]

MFN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1T3J
Identifiers
Aliases	MFN1, hfzo1, hfzo2, mitofusin 1
External IDs	OMIM: 608506; MGI: 1914664; HomoloGene: 11481; GeneCards: MFN1; OMA:MFN1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q26.33 Start 179,347,709 bp[1] End 179,394,936 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 A3|3 15.75 cM Start 32,583,614 bp[2] End 32,633,388 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon body of pancreas gastric mucosa epithelium of colon right hemisphere of cerebellum right uterine tube right auricle of heart skin of leg canal of the cervix Top expressed in myocardium of ventricle digastric muscle right ventricle cardiac muscle tissue of left ventricle extraocular muscle soleus muscle extensor digitorum longus muscle muscle of thigh thoracic diaphragm sternocleidomastoid muscle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding hydrolase activity GTPase activity Cellular component cytoplasm mitochondrial outer membrane mitochondrion membrane integral component of mitochondrial outer membrane outer mitochondrial membrane protein complex integral component of membrane intrinsic component of mitochondrial outer membrane Biological process mitochondrial fusion macroautophagy GTP metabolic process mitochondrion localization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55669 67414 Ensembl ENSG00000171109 ENSMUSG00000027668 UniProt Q8IWA4 Q811U4 RefSeq (mRNA) NM_017927 NM_033540 NM_024200 RefSeq (protein) NP_284941 NP_077162 Location (UCSC) Chr 3: 179.35 – 179.39 Mb Chr 3: 32.58 – 32.63 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.^[7]