Dynein, axonemal, heavy chain 14

Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene.^[5]

DNAH14
Identifiers
Aliases	DNAH14, C1orf67, Dnahc14, HL-18, HL18, dynein axonemal heavy chain 14
External IDs	OMIM: 603341; MGI: 2444525; HomoloGene: 90078; GeneCards: DNAH14; OMA:DNAH14 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 224,896,262 bp[1] End 225,399,292 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4- H5 Start 181,404,124 bp[2] End 181,643,339 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis body of pancreas testicle anterior pituitary gonad buccal mucosa cell islet of Langerhans ventricular zone epithelium of colon Top expressed in spermatocyte testicle bone marrow spermatid zygote secondary oocyte granulocyte thymus primary oocyte morula More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule motor activity nucleotide binding cytoskeletal motor activity ATP binding minus-end-directed microtubule motor activity dynein light chain binding dynein intermediate chain binding dynein light intermediate chain binding Cellular component cytoplasm cell projection microtubule cytoskeleton cilium dynein complex Biological process microtubule-based movement cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127602 240960 Ensembl ENSG00000185842 ENSMUSG00000047369 UniProt Q0VDD8 n/a RefSeq (mRNA) NM_001145154 NM_001373 NM_144989 NM_001349911 NM_001349912 NM_001367479 NM_001367481 NM_172846 NM_001377039 RefSeq (protein) NP_001138626 NP_659426 NP_001336840 NP_001336841 NP_001354408 NP_001354410 n/a Location (UCSC) Chr 1: 224.9 – 225.4 Mb Chr 1: 181.4 – 181.64 Mb PubMed search [3] [4]
Wikidata
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Function

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).^[6]