E4F1

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.^[5][6][7]

E4F1
Identifiers
Aliases	E4F1, E4F, E4F transcription factor 1
External IDs	OMIM: 603022; MGI: 109530; HomoloGene: 3259; GeneCards: E4F1; OMA:E4F1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.3 Start 2,223,580 bp[1] End 2,235,742 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 A3.3|17 12.39 cM Start 24,662,752 bp[2] End 24,689,287 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum sural nerve right lobe of thyroid gland granulocyte left lobe of thyroid gland pituitary gland skin of leg skin of abdomen apex of heart anterior pituitary Top expressed in granulocyte neural layer of retina muscle of thigh lip right kidney superior frontal gyrus urethra morula morula ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity transcription coactivator activity metal ion binding protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding cAMP response element binding transferase activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm spindle nucleoplasm nucleus Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated cell division DNA replication regulation of mitotic cell cycle, embryonic protein ubiquitination regulation of growth cell cycle cell population proliferation viral process regulation of cell cycle process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1877 13560 Ensembl ENSG00000167967 ENSMUSG00000024137 UniProt Q66K89 Q8CCE9 RefSeq (mRNA) NM_001288776 NM_001288778 NM_004424 NM_001301784 NM_007893 NM_001355708 RefSeq (protein) NP_001275705 NP_001275707 NP_004415 NP_001288713 NP_031919 NP_001342637 Location (UCSC) Chr 16: 2.22 – 2.24 Mb Chr 17: 24.66 – 24.69 Mb PubMed search [3] [4]
Wikidata
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Function

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.^[7]

Interactions

E4F1 has been shown to interact with:

• P16,^[8]
• P53,^[8][9] and
• RB1^[10]