EAF2

ELL-associated factor 2 is a protein that in humans is encoded by the EAF2 gene.^[5][6][7] It is part of the EAF family of proteins and plays a role in transcriptional elongation by interacting with ELL proteins.^[8]

EAF2
Identifiers
Aliases	EAF2, BM040, TRAITS, U19, ELL associated factor 2
External IDs	OMIM: 607659; MGI: 2146616; HomoloGene: 10208; GeneCards: EAF2; OMA:EAF2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.33 Start 121,835,183 bp[1] End 121,886,526 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 36,613,246 bp[2] End 36,695,365 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells monocyte lymph node trabecular bone granulocyte appendix kidney tubule epithelium of nasopharynx rectum spleen Top expressed in female urethra right kidney proximal tubule lacrimal gland epithelium of urethra epithelium of female urethra seminal vesicula pelvic part of vagina male urethra epithelium of male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding protein binding Cellular component nuclear speck transcription elongation factor complex super elongation complex nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of cell growth negative regulation of epithelial cell proliferation involved in prostate gland development positive regulation of transcription by RNA polymerase II transcription, DNA-templated apoptotic process transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55840 106389 Ensembl ENSG00000145088 ENSMUSG00000022838 UniProt Q96CJ1 Q91ZD6 RefSeq (mRNA) NM_018456 NM_001320041 NM_001113401 NM_001113405 NM_134111 NM_001358102 RefSeq (protein) NP_001306970 NP_060926 NP_001106872 NP_001106876 NP_598872 NP_001345031 Location (UCSC) Chr 3: 121.84 – 121.89 Mb Chr 16: 36.61 – 36.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse