EBAG9

Receptor-binding cancer antigen expressed on SiSo cells is a protein that in humans is encoded by the EBAG9 gene.

EBAG9
Identifiers
Aliases	EBAG9, EB9, PDAF, estrogen receptor binding site associated, antigen, 9, estrogen receptor binding site associated antigen 9
External IDs	OMIM: 605772; MGI: 1859920; HomoloGene: 3107; GeneCards: EBAG9; OMA:EBAG9 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q23.2 Start 109,539,711 bp[1] End 109,565,996 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 B3.2 Start 44,482,571 bp[2] End 44,504,911 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland corpus epididymis caput epididymis endothelial cell Achilles tendon kidney tubule tail of epididymis Brodmann area 23 Epithelium of choroid plexus glomerulus Top expressed in seminal vesicula parotid gland submandibular gland atrioventricular valve tail of embryo triceps brachii muscle endocardial cushion genital tubercle migratory enteric neural crest cell ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activator activity involved in apoptotic process Cellular component integral component of membrane Golgi apparatus secretory granule membrane Golgi membrane Biological process regulation of cell growth apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9166 55960 Ensembl ENSG00000147654 ENSMUSG00000022339 UniProt O00559 Q9D0V7 RefSeq (mRNA) NM_198120 NM_001278938 NM_004215 NM_019480 NM_001357690 NM_001357691 RefSeq (protein) NP_001265867 NP_004206 NP_936056 NP_062353 NP_001344619 NP_001344620 Location (UCSC) Chr 8: 109.54 – 109.57 Mb Chr 15: 44.48 – 44.5 Mb PubMed search [3] [4]
Wikidata
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This gene was identified as an estrogen-responsive gene. Regulation of transcription by estrogen is mediated by estrogen receptor which binds to the estrogen-responsive element (ERE) found in the 5'-flanking region of this gene. The encoded protein is a tumor-associated antigen that is expressed at high frequency in a variety of cancers. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.^[5]