EBF1

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.^[5][6][7]

EBF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LYR, 3MQI
Identifiers
Aliases	EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343; MGI: 95275; HomoloGene: 7297; GeneCards: EBF1; OMA:EBF1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 158,695,916 bp[1] End 159,099,916 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.1|11 26.45 cM Start 44,617,317 bp[2] End 45,008,091 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint synovial membrane Achilles tendon oocyte buccal mucosa cell skin of hip cardiac muscle tissue of right atrium parietal pleura vena cava spinal ganglia Top expressed in external carotid artery internal carotid artery trigeminal ganglion superior cervical ganglion spinal ganglia neural tube ankle lumbar spinal ganglion subcutaneous adipose tissue brown adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding metal ion binding DNA-binding transcription factor activity protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific C2H2 zinc finger domain binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus Biological process multicellular organism development regulation of transcription, DNA-templated transcription, DNA-templated regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1879 13591 Ensembl ENSG00000164330 ENSMUSG00000057098 UniProt Q9UH73 Q07802 RefSeq (mRNA) NM_001290360 NM_024007 NM_182708 NM_001324101 NM_001324103 NM_001324106 NM_001324107 NM_001324108 NM_001324109 NM_001324111 NM_001364155 NM_001364156 NM_001364157 NM_001364158 NM_001364159 NM_001290709 NM_001290710 NM_001290711 NM_007897 RefSeq (protein) NP_001277289 NP_001311030 NP_001311032 NP_001311035 NP_001311036 NP_001311037 NP_001311038 NP_001311040 NP_076870 NP_874367 NP_001351084 NP_001351085 NP_001351086 NP_001351087 NP_001351088 NP_001277638 NP_001277639 NP_001277640 NP_031923 NP_001349498 NP_001349500 NP_001349503 NP_001349504 NP_001349505 NP_001349506 NP_001349507 NP_001349508 Location (UCSC) Chr 5: 158.7 – 159.1 Mb Chr 11: 44.62 – 45.01 Mb PubMed search [3] [4]
Wikidata
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EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.^[8][9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.^[10] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.^[11]

Interactions

EBF1 has been shown to interact with ZNF423^[12] and CREB binding protein.^[13]