EBI3

Epstein-Barr virus induced gene 3, also known as interleukin-27 subunit beta or IL-27B, is a protein which in humans is encoded by the EBI3 gene.^[5][6]

EBI3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 7U7N, 7Z0L, 7ZG0, 7ZXK, 8D85
Identifiers
Aliases	EBI3, IL-27B, IL27B, Epstein-Barr virus induced 3, IL35B
External IDs	OMIM: 605816; MGI: 1354171; HomoloGene: 4207; GeneCards: EBI3; OMA:EBI3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 4,229,523 bp[1] End 4,237,528 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 D|17 29.08 cM Start 56,259,640 bp[2] End 56,264,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta decidua spleen appendix lymph node gonad gallbladder right adrenal gland C1 segment right coronary artery Top expressed in granulocyte splanchnocranium rib hyoid bone humerus stroma of bone marrow sphenoid bone Meckel's cartilage lesser wing of sphenoid bone tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine receptor activity cytokine activity interleukin-27 receptor binding protein binding ciliary neurotrophic factor receptor activity cytokine binding Cellular component extracellular region plasma membrane membrane extracellular space endoplasmic reticulum lumen external side of plasma membrane receptor complex ciliary neurotrophic factor receptor complex CNTFR-CLCF1 complex Biological process T-helper 1 type immune response T cell proliferation humoral immune response positive regulation of alpha-beta T cell proliferation regulation of signaling receptor activity interleukin-27-mediated signaling pathway interleukin-35-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10148 50498 Ensembl ENSG00000105246 ENSMUSG00000003206 UniProt Q14213 O35228 RefSeq (mRNA) NM_005755 NM_015766 RefSeq (protein) NP_005746 NP_056581 Location (UCSC) Chr 19: 4.23 – 4.24 Mb Chr 17: 56.26 – 56.26 Mb PubMed search [3] [4]
Wikidata
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Function

This gene was identified by the induction of its expression in B lymphocytes by Epstein–Barr virus infection. The protein encoded by this gene is a secreted glycoprotein, which is a member of the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). It plays a role in regulating cell-mediated immune responses.^[7]

EBI3 is a subunit in 2 distinct heterodimeric cytokines: interleukin-27 (IL27) and IL35. IL27 is composed of p28 (IL27) and EBI3. IL27 can trigger signaling in T cells, B cells, and myeloid cells.^[8] IL35, an inhibitory cytokine involved in regulatory T-cell function, is composed of EBI3 and the p35 subunit of IL12.^[7][9]